The Vascular Component of Behavioral Variant Frontotemporal Dementia

 
   Lead Investigator:    Vladimir Hachinski
   Institution      :    London Health Sciences Centre, Western Ontario U.
   E-Mail           :    lsposato@uwo.ca
   Proposal ID      :    415


   Publications:


1  Torralva T, Sposato L, Roca M, Gleichgerrcht E, Riccio PM, Hachinski V, Manes F
   The Role of Cerebrovascular Disease in Behavioral Variant Frontotemporal Dementia
   2014   Abstract  Am J Neurodegener Dis   3(Suppl. 1)   , 

   PUBLISHED



2  Torralva T, Sposato LA, Riccio PM, Gleichgerrcht E, Roca M, Toledo JB, Trojanowski JQ,  Kukull WA , Manes F, Hachinski V
   Role of brain infarcts in behavioral variant frontotemporal dementia: Clinicopathological characterization in the National Alzheimer's Coordinating Center database
   Journal Article  Neurobiol Aging,36:2861-2868,2015,PMC4562890

   PUBLISHED





   Proposal Description:
   Identifying distinctive vascular risk factor, cognitive, and functional profiles for bvFTD, may result in a better clinical characterization of patients with suspicion of bvFTD and coexistent cerebrovascular disease.  The objective of the present study is to compare patients with a clinical-neuropathological diagnosis bvFTD and a vascular component vs. those with bvFTD without vascular component, and vs. those with neuropathological diagnosis of primary cerebrovascular disease, in order to: (a) characterize their demographic and vascular risk factor profiles (b) individualize distinct neuropsychological and functional characteristics inherent to each condition and (c) identify differential neuropathological findings to better understand the underlying pathophysiology of each clinical/neuropsychological syndrome.